Antifungal Agents Diflucan
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Diflucan
Active Ingredients:
- Fluconazole
The commercial name of the medication may differ from the brand one. Generic Diflucan manufactured by Inison Pharmaceuticals is available under commercial name Fole.
How does the medication work?
Antifungal agent. Selective inhibitor of sterol synthesis in the cell of fungi. Effective in opportunistic mycoses, including generalized candidiasis (also with reduced immunity), cryptococcal infection (caused by Cryptococcus neoformans, including meningitis), infection caused by Microsporum spp. and Trychoptyton spp., endemic mycoses (caused by Blastofnyces oermatitioes, Coccidkxtes immitis, Histoplasma capsulatum).
Why is Diflucan prescribed?
- Cryptococcosis, including cryptococcal meningitis and infections of lung and skin in patients with normal immune response and AIDS, recipients of transplanted organs and patients with other forms of immunodeficiency; for maintenance therapy to prevent cryptococcosis backset in AIDS patients;
- Generalized candidiasis, including candidemia, disseminated candidiasis and other forms of invasive Candida infections (infection of the peritoneum, endocardium, eyes, respiratory and urinary tract, including in patients with malignant tumors, intensive care unit patients, patients receiving cytotoxic or immunosuppressive medications predisposed to candidiasis;
- Candidiasis of mucous membranes, including oral cavity and pharynx, esophagus, non-invasive pulmonary candidiasis, mucocutaneous and chronic oral atrophic candidiasis in patients with normal and suppressed immune function, prevention of oropharyngeal candidiasis backset in AIDS patients;
- Genital candidiasis: acute or recurrent vaginal candidiasis, candidiasis balanitis; prophylaxis to reduce the frequency of recurrences of vaginal candidiasis (3 or more episodes per year);
- Prevention of fungal infections in patients with malignant tumors receiving cytotoxic chemotherapy or radiotherapy;
- Mycosis of the skin, including mycosis of the feet, body, groin, scaly skin disease, onychomycosis and cutaneous Candida infections;
- Deep endemic mycosis in patients with normal immunity.
When Diflucan should not be taken?
- Hypersensitivity
- Pregnancy, breastfeeding
- With caution: liver and / or renal dysfunction, risk of heart arrhythmias, heart disorders
What side effects are possible with the medicine ?
- gastrointestinal tract: nausea, abdominal pain, diarrhea, bloating, taste disturbance, abnormal liver function, increased bilirubin or liver aminotransferases in serum, hepatitis
- nervous system: headache, dizziness, cramps
- blood system: leukopenia, neutropenia, agranulocytosis, thrombocytopenia
- dermatological and allergic reactions: skin rash, urticaria, angioedema, anaphylactic reactions, exfoliative skin disorders (Stevens-Johnson syndrome, toxic epidermal necrolysis), alopecia
- other: increased QT interval on ECG, increased cholesterol and triglycerides in the blood plasma, hypokaliemia
If any of these side effects occur during the treatment seek medical attention immediately.
This is not a full list of possible Fluconazole side effects. If you notice other adverse effects caused by the preparation inform your doctor or pharmacist.
What are possible drug to drug interactions associated with Diflucan?
Diflucan can interact with the following groups of drugs:
- anticoagulants
- drugs that are metabolized by cytochrome P450
- sulphonylurea agents
- diuretics
- anticonvulsants
- anti-tuberculosis drugs
- immunosuppressive agents
- bronchodilators
- drugs that prolong QT interval
- antibiotics
- antiviral medications
- hypnotics
- anesthetic medications
Let your doctor know if you are taking any of the above mentioned medicines or other preparations including herbals, vitamins and food supplements as they may change the effectiveness or increase the risk of Fluconazole side effects.
Additional drug information
The medicines should be kept out of reach and sight of children. You should take the medicine exactly as prescribed by your doctor. Avoid off-label use of the medication. If you are unsure about anything related to Fluconazole contact your health care provider or pharmacist. You can also apply to our customer support service.
