Antiplatelet Agents Plavix
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Plavix
Active Ingredients:
- Clopidogrel Bisulfate
How does the medication work?
Clopidogerel belongs to a group of medicines called inhibitors of platelet aggregation. The medication binds to ADP-receptors of the platelets and selectively inhibits the connection of ADP with ADP-receptors and activation of GPIIb/IIIa. All of these leads to inhibiting ADP-induced platelets aggregation. Clopidogrel also inhibits platelets aggregation caused by other agonists. Clopidogrel helps to prevent the development of atherothrombosis in cerebral, coronal and peripheral arteries.Why is Plavix prescribed?
- Prophylaxis of atherothrombosis in patients with heart attacks and ischemic stroke or with diagnosed occlusive disease of peripheral arteries.
Prevention of atherothrombotic conditions (in combination with acid acetyl salicylic) in patients with acetyl salicylic acid:
- Unstable angina and heart attacks without Q segment
- Acute myocardial infarction (raised ST segments) in medicinal therapy
When Plavix should not be taken?
Generic Plavix should not be taken in:
- Severe liver failure
- Acute pathological bleedings (bleedings from peptic ulcers or intra-cranial bleedings)
- Pregnancy
- Breastfeeding
- Galactose intolerance, lactose deficiency, glucose-galactose malabsorbtion.
The medication should be used with caution in moderate liver failure, tendency to bleedings, kidney failure, traumas, surgical interventions, concomitant use of NSAID's, warfarin, heparin, inhibitors of glycoproteins of IIb/IIIа. The medication should be used with caution in liver or kidney disease, post operative conditions.
What side effects are possible with the medicine ?
Generic Plavix may cause the following side effects:
- Major bleedings
- Flu-like symptoms
- Itchy skin
- Headache
- Nasal bleedings
- Bruising
- Bloody nose
- Pain
- Dizziness
- Blood in the urine
- Bloody stool
- Skin rash
- Constipation
- Urinary tract infections
- High blood pressure
- Stomach bleedings
- Joint pain
- Fatigue
If any of these side effects occur during the treatment seek medical attention immediately.
This is not a full list of possible Plavix side effects. If you notice other adverse effects caused by the preparation inform your doctor or pharmacist.
What are possible drug to drug interactions associated with Plavix?
Clopidogrel should not be taken in combination with:
- Blood thinners (warfarin)
- NSAID's
- Epileptic seizures treatment (phenytoin)
- Breast cancer prophylaxis (tamoxifen)
- Diuretics (torsemide)
- High cholesterol treatment (fluvastatin)
- Certain herbals like Ginseng, St.John's wort, Garlic, Ginger and others.
Let your doctor know if you are taking any of the above mentioned medicines or other preparations including herbals, vitamins and food supplements as they may change the effectiveness or increase the risk of Plavix side effects.
Additional drug information
The medicines should be kept out of reach and sight of children. You should take the medicine exactly as prescribed by your doctor. Avoid off-label use of the medication. If you are unsure about anything related to Plavix contact your health care provider or pharmacist. You can also apply to our customer support service.
