Cholesterol Crestor
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Crestor
Active Ingredients:
- rosuvastatin calcium
How does the medication work?
Crestor belongs to a group of anticholesterol medicines called statins. Action mechanism of the medication consists in inhibiting the enzyme called HMG-CoA reductase which is responsible for the production cholesterol. By decreasing the production of cholesterol in the liver, rosuvastatin causes LDL receptors to collect more collect more cholesterol from the blood. This helps to reduce cholesterol blood levels. Therapeutic effects of the medication occurs in a week and reaches its maximum in 4 weeks.
Why is Crestor prescribed?
The medication is prescribed for the treatment of the following conditions:
- Primary hypercholesterolemia (type II including familiar heterozygous hypercholesterolemia)
- Mixed hypercholesterolemia
- Familiar homozygous hypercholesterolemia
- Lowering the risk of heart attacks or strokes in patients with atherosclerosis.
When Crestor should not be taken?
You should avoid taking Crestor if any of the following conditions apply:
- Active phase of liver diseases
- Severe kidney failure (creatinine clearance less than 30nml/min)
- Myopathy
- Pregnancy
- Breastfeeding
- Hypersensitivity to any of the medication ingredients
- Tendency to myelotoxic complications
- Children and adolescents
Generic Crestor should be used with caution in: liver diseases in anamnesis, sepsis, arterial hypotension, surgical interventions, traumas, severe metabolic, endocrine and electrolyte disorders, uncontrolled epilepsy, high risk of epilepsy: kidney failure, hyperthyrosis, muscle diseases, elderly patients (over 65 years of age), Asian race.
What side effects are possible with the medicine ?
- Allergic reactions: hives, angioedema
- CNS and peripheral nervous system: headache, dizziness, polyneuropathy
- Digestive system: constipation, nausea, stomach pain, increased activity of liver's enzymes, jaundice, hepatitis.
- Dermatological reactions: itching, rash.
- Apparatus system: myalgia, myopathy, rhabdomyolysis, arthralgia.
- Urogenital system: proteinuria
- Other: asthenia
If any of these side effects occur during the treatment seek medical attention immediately.
This is not a full list of possible Crestor side effects. If you notice other adverse effects caused by the preparation inform your doctor or pharmacist.
What are possible drug to drug interactions associated with Crestor?
- Immune suppression therapy (cyclosporine)
- Antacids
- Oral contraceptives
- H-2 histamine receptors blockers (cimetidine)
- Fibrates (fenofibrate, gemfibrozil)
- Niacin containing preparations
- Protease inhibitors
- Potassium sparing diuretics (spironolactone)
- Red yeast rice
- Antimycotics (ketoconazole)
- Blood thinners (warfarin)
Let your doctor know if you are taking any of the above mentioned medicines or other preparations including herbals, vitamins and food supplements as they may change the effectiveness or increase the risk of Crestor side effects.
Additional drug information
The medicines should be kept out of reach and sight of children. You should take the medicine exactly as prescribed by your doctor. Avoid off-label use of the medication. If you are unsure about anything related to Crestor contact your health care provider or pharmacist. You can also apply to our customer support service.
