Cholesterol Lipitor
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Lipitor
Active Ingredients:
- atorvastatin
The commercial name of the medication may differ from the brand one. Generic Lipitor manufactured by Cadila Pharmaceuticals is available under commercial name Atorbest.
How does the medication work?
Atorvastatin is a part of anti-cholesterol medication called statins. Action mechanism of the medication is related to inhibiting the activity of enzymes called HMG-CoA-reductase. This enzyme is responsible for catalyzing the conversion of HMG-CoA into the mevalonic acid. Mevalonic acid is a substratum in biosynthesis of cholesterol in the organism. The inhibiting of cholesterol production leads to increased reactivity of LDL receptors which collect and metabolize low density lipoproteins from the blood.
Antisclerosthic effects of the medication is associated with lowering the amount of cholesterol, low density lipoproteins, apolipoprotein B, triglycerides. The medication increases the amount of HDL which is sometimes called good'' cholesterol. The effects of the medication is observed in two weeks after beginning of the therapy. Maximal therapeutic effect is observed in four weeks.
Why is Lipitor prescribed?
Lipitor is used in the treatment of the following conditions:
- Primary hypercholesterolemia (lowering high cholesterol blood levels)
- Hypertriglyceridemia
- Mixed hyperlipidemia (including and patients with insulin dependent diabetes)
- Homozygous and heterozygous familial hypercholesterolemia
- Lowering the risk of cardiovascular complications (heart attacks, strokes) associated with atherosclerosis
When Lipitor should not be taken?
Lipitor should not taken if any of the following health conditions apply to you:
- Liver diseases in active stage (including chronic hepatitis, chronic alcoholic hepatitis)
- Liver failure
- Liver cirrhosis of unknown origin
- Increases activity to liver's transaminases of unknown origin
- Diseases of the skeletal muscles
- Pregnancy
- Breastfeeding
- Children under 18 years of age
The medication should be used with caution in: chronic alcoholism, severe disorders of electrolyte balance, endocrine and metabolic disorders, arterial hypotension, severe acute infections (sepsis), uncontrolled epilepsy, surgical interventions, trauma.
What side effects are possible with the medicine ?
Generic Lipitor may cause the following side effects:
- CNS: headache, drowsiness, asthenia, insomnia, dizziness, nightmares, paresthesia, peripheral neuropathy, emotional lability, ataxia, hyperkinesis, depression, hyperesthesia
- Sense organs: tinnitus, dryness of the conjunctiva, accommodation disorders, loss of taste, glaucoma, deafness
- Cardiovascular system: increased heart rate, vasodilation, migraine, postural hypotension, increased blood pressure, phlebitis, arrhythmia
Haemopoietic system: anemia, thrombocytopenia, lymphadenopathy.
- Respiratory system: bronchitis, rhinitis, bronchial asthma, nasal bleedings, dyspnoe.
Digestive system: nausea, heartburn, constipation, diarrhea, meteorism, stomach pain, abdominal pain, anorexia, increased appetite, dry mouth, belching, dysphagia, vomiting, stomatitis, esophagitis, glossitis, gastroenteritis, hepatitis, liver colic, pancreatitis, jaundice, increased activity of liver's enzymes, rectal bleedings, melena, tenesmus.
- Apparatus system: arthritis, seizures, bursitis, myositis, myopathy, arthralgia, myalgia, rhabdomyolysis, joint seizures
- Urogenital system: urogenital infections, dysuria, urine retention, cystitis, hematuria, vaginal bleedings, uterine bleedings, decreased libido, erectile dysfunction, ejaculation disorders.
Dermatological reactions: alopecia, sweating, eczema, seborrhea
- Allergic reactions: itching, rash, contact dermatitis, hives, angioedema
- Laboratory indexes: hyperglycemia, hypoglycemia, albuminuria, increased activity of GPT, GOT.
- Other: peripheral edema, increased body weight, gynecomastia, aggravation of gout.
If any of these side effects occur during the treatment seek medical attention immediately.
This is not a full list of possible Lipitor side effects. If you notice other adverse effects caused by the preparation inform your doctor or pharmacist.
What are possible drug to drug interactions associated with Lipitor?
Lipitor may interact with the following medicines:
- Cyclosporine
- Antibiotics (erythromycin, clarithromycin)
- Protease inhibitors (HIV drugs)
- Anti-mycotic agents (fluconazole, itraconazole, ketoconazole)
- Other statins
- Fibrates
- Niacin containing drugs or supplements
- Antiseizure agents (phenytoin)
- Antacids
- Oral contraceptives
- Cardiac glycosides (digoxin)
- Blood thinners (warfarin)
- Grape fruit juice
Let your doctor know if you are taking any of the above mentioned medicines or other preparations including herbals, vitamins and food supplements as they may change the effectiveness or increase the risk of Lipitor side effects.
Additional drug information
The medicines should be kept out of reach and sight of children. You should take the medicine exactly as prescribed by your doctor. Avoid off-label use of the medication. If you are unsure about anything related to Lipitor contact your health care provider or pharmacist. You can also apply to our customer support service.
