Cholesterol Mevacor
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Mevacor
Active Ingredients:
- lovastatin
How does the medication work?
Mevacor is hypolipidemic preparation which belongs to a group of medicines called statins. Mevacor works by inhibiting the enzyme called HMG-CoA-reductase. Being a prodrug, Lovastatin contains in its structure lactone ring which is hydrolyzed in the liver into its active form. Lactone ring of statins is similar to the active part of HMG-Co-reductase. This part of lovastatin's molecule binds to HMG-Co-reductase, another part of molecule inhibits the conversion of hydroxymethylglutarate into mevalonate which is intermediate product in the synthesis of cholesterol. Inhibiting the enzyme HMG-Co-reductase leads lowering of cholesterol production in livers. This results in increased activity of LDL receptors causing intensive catabolism of cholesterol (LDL).
Lovastatin also increases the blood levels of good cholesterol called HDL (high density lipoproteins).
Why is Mevacor prescribed?
Generic Mevacor is used for reducing the blood levels of low density lipoproteins in patients with primary hypercholesterolemia and mixed hyperlipidemoa (type 2a and 2b) when special diet and physical exercises do not bring the positive therapeutic effect.
When Mevacor should not be taken?
Lovastatin should not be used if any of the following conditions apply to you:
- Acute diseases of the liver
- Uncreased activity of liver's transaminases
- Pregnancy
- Breastfeeding
- Hypersensitivity to any of the medication ingredients
What side effects are possible with the medicine ?
Generic Mevacor may cause the following side effects:
- Digestive system: taste changes, dry mouth, anorexia, nausea, diarrhea, constipation, meteorism, increased activity of liver's transaminases, in individual cases jaundice, hepatitis, pancreatitis.
- CNS and peripheral nervous system: dizziness, headache, insomnia, seizures, paresthesia, mental disorders.
- Apparatus system: myalgia, myopathy, myositis, rhabdomyolysis
- Hemopoietic system: anemia, leukopenia, thrombocytopenia
- Allergic reactions: skin rash, hives, Quincke's edema, toxic epidermal necrolysis
If any of these side effects occur during the treatment seek medical attention immediately.
This is not a full list of possible Mevacor side effects. If you notice other adverse effects caused by the preparation inform your doctor or pharmacist.
What are possible drug to drug interactions associated with Mevacor ?
Generic Mevacor may interact with the following medicines:
- Anti-arrhythmic medicines (amiodarone)
- Certain antibiotics (aerythromycin, clarithromycin, telithromycin)
- Certain antimycotic agents (fluconazole, ketoconazole, itraconazole, miconazole)
- Immune suppression therapy (cyclosporine)
- Other cholesterol preparations including fibrates and statins
- Steroids (danazol)
- Antidepressants (Nefazodone)
- Niacin containing drugs
- Protease inhibitors
- Calcium channel blockers (verapamil)
- Grape fruit juice
- Blood thinners (warfarin)
Let your doctor know if you are taking any of the above mentioned medicines or other preparations including herbals, vitamins and food supplements as they may change the effectiveness or increase the risk of Mevacor side effects.
Additional drug information
The medicines should be kept out of reach and sight of children. You should take the medicine exactly as prescribed by your doctor. Avoid off-label use of the medication. If you are unsure about anything related to Mevacor contact your health care provider or pharmacist. You can also apply to our customer support service.
