Cholesterol Pravachol
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Pravachol
Active Ingredients:
- pravastatin
How does the medication work?
Pravachol belongs to a group of anticholesterol medicines called statins. Action mechanism of the medication is associated with inhibiting the enzyme called HMG-Coa-reductase. A molecule of statin binds to CoA of the enzyme and another part of the molecule inhibits the conversion of hydroxymethylglutarate to mevalonate. Inhibiting the activity of HMG-CoA-reductase leads to decreasing the amount of cholesterol produced by the liver. Decreased production of cholesterol causes liver to collect more cholesterol from the blood. Pravastatin lowers the blood levels of low density and very low density lipoproteins, increases the blood concentration of high density lipoproteins.
Why is Pravachol prescribed?
Pravachol is prescribed for the treatment of the following conditions:
- Hyperlipoproteinemia 2a and 2b types
- Increased triglycerides blood levels
- Prophylaxis of heart attacks and strokes associated with atherosclerosis
- Decreasing the risk of cardiovascular complications caused by atherosclerosis
When Pravachol should not be taken?
You should not take Pravachol if any of the following conditions apply to:
- Hypersensitivity to any of the medication ingredient
- Acute liver diseases
- Acute kidney diseases
- Severe cardiovascular diseases including heart attacks and strokes
- Increased activity of liver's transaminase of unknown origin
- Pregnancy
- Breastfeeding
You should let your health care provider know if:
- you drink alcoholic beverages frequently
- you are undergoing any surgical interventions
What side effects are possible with the medicine ?
- CNS: dizziness, headache, taste changes, abnormal eyes movements, paresis of the facial nerve, peripheral polyneuropathy, tremor, anxiety, insomnia, depression, amnesia, paresthesia.
- Vision organs: aggravation of cataract, oftalmoplegia
- Digestive system: nausea, vomiting, diarrhea, stomach pain, meteorism, constipation, increased activity of liver's transaminases, in individual cases- hepatitis, fatty liver's infiltration, liver cirrhosis, hepatoma, acute pancreatitis.
- Hemopoetic system: thrombocytopenia, leukopenia, hemolytic anemia, eosinophilia
- Apparatus system: myalgia, myopathy, myositis, rhabdomyolysis
- Allergic reactions: skin rash, itching, anaphylactic shock, dermatomyositis, vasculitis, purpura, erythema, toxic epidermal necrolysis
- Dermatological reactions: alopecia, dryness of the skin and mucous linings
- Other: decreased libido, erectile dysfunction, gynecomastia, increased heart rate, breathing disorders, kidney failure, myoglobinuria, kidney failure.
If any of these side effects occur during the treatment seek medical attention immediately.
This is not a full list of possible Pravachol side effects. If you notice other adverse effects caused by the preparation inform your doctor or pharmacist.
What are possible drug to drug interactions associated with Pravachol?
Generic Pravachol may interact with the following medicines:
- Antifungal agents (ketoconazole, itraconazole, fluconazole, miconazole, posaconazole, voriconazole)
- Immune suppression therapy (cyclosporine)
- Certain antibiotics (erythromycin)
- Fibrates (fenofibrate, gemfibrozil)
- Niacin containing supplements and drugs
Let your doctor know if you are taking any of the above mentioned medicines or other preparations including herbals, vitamins and food supplements as they may change the effectiveness or increase the risk of Pravachol side effects.
Additional drug information
The medicines should be kept out of reach and sight of children. You should take the medicine exactly as prescribed by your doctor. Avoid off-label use of the medication. If you are unsure about anything related to Pravachol contact your health care provider or pharmacist. You can also apply to our customer support service.
