Diabetes Treatment Actos
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Actos
Active Ingredients:
- Pioglitazone
How does the medication work?
Antidiabetic hypoglycemic drug for oral administration, derivative of thiazolidinediones. Selectively stimulates the nuclear gamma receptors activated by peroxisome proliferator-activated receptors-gamma (PPAR-gamma agonist). Activation of the nuclear PPAR-gamma modulates the transcription of genes that are sensitive to insulin and are involved in control of glucose level, lipid metabolism in the liver, in the adipose and muscle tissues.
Actos lowers insulin resistance of peripheral tissues and liver and, as a result, increases the insulin-dependent glucose consumption and reduces glucose release from the liver. In type II diabetes reduced insulin resistance under the action Actos causes a decrease in the concentration of glucose, insulin level and glycated hemoglobin in blood plasma. In monotherapy and in combination with sulfonylureas, metformin, or insulin Actos improves control of blood sugar.
In type II diabetes with violation of lipid metabolism, Actos reduces the triglycerides level and raises HDL without altering LDL and total cholesterol in the blood plasma.
Why is Actos prescribed?
- diabetes mellitus (II type) - as monotherapy or in combination with derivatives of sulfonylurea, metformin, or insulin if diet therapy, exercises, and monotherapy with one of the above drugs were inefficient
When Actos should not be taken?
- Hypersensitivity to pioglitazone or to one of the components of Actos
- Insulin-dependent diabetes mellitus (type I)
- Diabetic ketoacidosis
- Acute liver disease
- If the level of alanine aminotransferase is higher than normal in 2.5 times and more
- Pregnancy and breastfeeding
- With caution: edema, moderate increase of liver enzymes level, pediatric and adolescent patients
What side effects are possible with Actos ?
- Hypoglycemia
- Edema
- Anemia, decreased hemoglobin and hematocrit
- Increased alanine aminotransferase / ALT and creatine phosphokinase / CPK in blood plasma.
If any of these side effects occur during the treatment seek medical attention immediately.
This is not a full list of possible Pioglitazone side effects. If you notice other adverse effects caused by the preparation inform your doctor or pharmacist.
What are possible drug to drug interactions associated with Actos?
Actos is known to interact with the following groups of drugs:
- derivatives of sulfonylurea, metformin and insulin
- oral birth control pills
- antifungal agents
Let your doctor know if you are taking any of the above mentioned medicines or other preparations including herbals, vitamins and food supplements as they may change the effectiveness or increase the risk of Pioglitazone side effects.
Additional drug information
The medicines should be kept out of reach and sight of children. You should take the medicine exactly as prescribed by your doctor. Avoid off-label use of the medication. If you are unsure about anything related to Pioglitazone contact your health care provider or pharmacist. You can also apply to our customer support service.
